New Delhi, Nov 29 (IANS) A team of US researchers has developed a novel Artificial Intelligence (AI)-based tool that can pick subtle signs of Alzheimer’s disease that emerge decades before a formal diagnosis is made.
The signs are often in the form of irregular behaviors that reflect very early stages of brain dysfunction.
The team from Gladstone Institutes in California engineered mice to mimic key aspects of Alzheimer’s and used the new video-based machine learning tool to detect early signs of the brain disease.
The findings, published in the journal Cell Reports, sheds light on a new strategy for identifying neurological disease earlier than currently possible and tracking how it develops over time.
Gladstone investigator Jorge Palop said that AI can potentially revolutionise how the analysis of Alzheimer’s-linked behaviours — indicative of early abnormalities in brain function — is conducted.
The machine learning platform called VAME, (Variational Animal Motion Embedding) analysed video footage of mice exploring an open arena. It identified subtle behavioral patterns — disorganised behaviour, unusual patterns and transitioning more often between different activities — as the mice aged. These behaviours, likely associated with memory and attention deficits, were captured on camera but may not be noticed by simply looking at the mice.
The tool may help decode the origin and progression of the devastating brain disorders, Palop said, noting it can also be applied to other neurological diseases.
Further, the new study also used VAME to learn whether a potential therapeutic intervention for Alzheimer’s would prevent disorganised behavior in mice.
They found that genetically blocking a blood-clotting protein called fibrin from triggering toxic inflammation in the brain can prevent the development of abnormal behaviors in Alzheimer’s mice.
The team said the intervention also tackled the spontaneous behavioral changes in Alzheimer’s mice.
–IANS
rvt/
Disclaimer
The information contained in this website is for general information purposes only. The information is provided by TodayIndia.news and while we endeavour to keep the information up to date and correct, we make no representations or warranties of any kind, express or implied, about the completeness, accuracy, reliability, suitability or availability with respect to the website or the information, products, services, or related graphics contained on the website for any purpose. Any reliance you place on such information is therefore strictly at your own risk.
In no event will we be liable for any loss or damage including without limitation, indirect or consequential loss or damage, or any loss or damage whatsoever arising from loss of data or profits arising out of, or in connection with, the use of this website.
Through this website you are able to link to other websites which are not under the control of TodayIndia.news We have no control over the nature, content and availability of those sites. The inclusion of any links does not necessarily imply a recommendation or endorse the views expressed within them.
Every effort is made to keep the website up and running smoothly. However, TodayIndia.news takes no responsibility for, and will not be liable for, the website being temporarily unavailable due to technical issues beyond our control.
For any legal details or query please visit original source link given with news or click on Go to Source.
Our translation service aims to offer the most accurate translation possible and we rarely experience any issues with news post. However, as the translation is carried out by third part tool there is a possibility for error to cause the occasional inaccuracy. We therefore require you to accept this disclaimer before confirming any translation news with us.
If you are not willing to accept this disclaimer then we recommend reading news post in its original language.
