HomeTechnologyMicrobes deep within Arctic Sea yield promising prospects for antibiotics: Study 

Microbes deep within Arctic Sea yield promising prospects for antibiotics: Study 

New Delhi, Aug 30 (IANS) A team of Finnish researchers has developed a new suite of methods to test for the antivirulence and antibacterial effect of hundreds of unknown compounds from the Arctic Sea.

The team from the University of Helsinki targeted an enteropathogenic E. coli (EPEC) strain that causes severe diarrhoea in children under five, especially in developing countries. The compounds were derived from four species of actinobacteria and tested against EPEC adhering to colorectal cancer cells.

EPEC causes disease by adhering to cells in the human gut. Once it adheres to these cells, EPEC injects so-called “virulence factors” into the host cell to hijack its molecular machinery, ultimately killing it.

Two compounds showed strong antivirulence or antibacterial activity: one from an unknown strain (T091-5) in the genus Rhodococcus and another from an unknown strain (T160-2) of Kocuria. The compound from T091-5 was most likely a phospholipid, a class of fatty phosphorus-containing molecules that play important roles in cell metabolism.

“Here we show how advanced screening assays can identify antivirulence and antibacterial metabolites from actinobacteria extracts,” said Dr. Paivi Tammela, a professor at the University of Helsinki in Finland.

The molecule from T091-5 did not inhibit the development of EPEC bacteria, in contrast to the compounds from T160-2.

Of the two strains, T091-5 is the most promising since EPEC is less likely to develop resistance to its antivirulence actions.

Using sophisticated analytical techniques, the team found that the active component from T091-5 was most likely a phospholipid — a family of fatty phosphorus-containing molecules vital for cell metabolism. But this is subject to further studies, they noted, in the paper published in the journal Frontiers in Microbiology.

“The next steps are the optimisation of the culture conditions for compound production and the isolation of sufficient amounts of each compound to elucidate their respective structures and further investigate their respective bioactivities,” said Tammela.

–IANS

ts/rvt/

Go to Source

Disclaimer

The information contained in this website is for general information purposes only. The information is provided by TodayIndia.news and while we endeavour to keep the information up to date and correct, we make no representations or warranties of any kind, express or implied, about the completeness, accuracy, reliability, suitability or availability with respect to the website or the information, products, services, or related graphics contained on the website for any purpose. Any reliance you place on such information is therefore strictly at your own risk.

In no event will we be liable for any loss or damage including without limitation, indirect or consequential loss or damage, or any loss or damage whatsoever arising from loss of data or profits arising out of, or in connection with, the use of this website.

Through this website you are able to link to other websites which are not under the control of TodayIndia.news We have no control over the nature, content and availability of those sites. The inclusion of any links does not necessarily imply a recommendation or endorse the views expressed within them.

Every effort is made to keep the website up and running smoothly. However, TodayIndia.news takes no responsibility for, and will not be liable for, the website being temporarily unavailable due to technical issues beyond our control.

For any legal details or query please visit original source link given with news or click on Go to Source.

Our translation service aims to offer the most accurate translation possible and we rarely experience any issues with news post. However, as the translation is carried out by third part tool there is a possibility for error to cause the occasional inaccuracy. We therefore require you to accept this disclaimer before confirming any translation news with us.

If you are not willing to accept this disclaimer then we recommend reading news post in its original language.

RELATED ARTICLES
- Advertisment -

Most Popular