New Delhi, Aug 7 (IANS) Donor-derived cell-free DNA (dd-cfDNA), also known as liquid biopsy, has the potential for early detection of kidney transplant rejection, a new study shows.
The international study enrolled kidney transplant recipients – both adult and paediatric – from 14 transplantation centres in Europe and the US.
In inflammation associated with transplant rejection, dying cells release donor-derived cell-free DNA (dd-cfDNA) into the bloodstream.
Researchers found that dd-cfDNA levels were strongly correlated with different types of transplant rejection, including antibody-mediated rejection, T cell-mediated rejection, and mixed rejection. The study found similar accuracy in both children and adults.
Currently, unnecessary and invasive graft biopsies are considered the “gold standard” for diagnosing transplant rejection. However, dd-cfDNA could provide a non-invasive, accurate biomarker to reduce the need for biopsy.
Two Indian origin Washington University School of Medicine researchers Raja Dandamudi, MD, and Vikas Dharnidharka, MD, MPH, contributed to the study, led by researchers from the Universite Paris Cite and doctors from the Assistance Publique – Hopitaux de Paris.
“Many studies of newer biomarkers to detect acute rejection in kidney transplants are not very large and cannot study various sub-populations, limiting their generalizability,” Dharnidharka said. This work was a very large international collaboration. The analyses demonstrated that dd-cfDNA improves the acute rejection detection beyond our standard of care monitoring, including in subpopulations of transplant recipients who are of African ancestry or of pediatric age.”
“This paper advances our understanding of the benefits of using cf-DNA as a biomarker for rejection and outcomes in the field of kidney transplantation.” said Tarek Alhamad, professor of Medicine at WashU Medicine.
While biopsies will continue as the method of rejection diagnosis, dd-cfDNA may improve early rejection diagnosis and enhance the care of kidney transplant recipients.
–IANS
ts/svn
Disclaimer
The information contained in this website is for general information purposes only. The information is provided by TodayIndia.news and while we endeavour to keep the information up to date and correct, we make no representations or warranties of any kind, express or implied, about the completeness, accuracy, reliability, suitability or availability with respect to the website or the information, products, services, or related graphics contained on the website for any purpose. Any reliance you place on such information is therefore strictly at your own risk.
In no event will we be liable for any loss or damage including without limitation, indirect or consequential loss or damage, or any loss or damage whatsoever arising from loss of data or profits arising out of, or in connection with, the use of this website.
Through this website you are able to link to other websites which are not under the control of TodayIndia.news We have no control over the nature, content and availability of those sites. The inclusion of any links does not necessarily imply a recommendation or endorse the views expressed within them.
Every effort is made to keep the website up and running smoothly. However, TodayIndia.news takes no responsibility for, and will not be liable for, the website being temporarily unavailable due to technical issues beyond our control.
For any legal details or query please visit original source link given with news or click on Go to Source.
Our translation service aims to offer the most accurate translation possible and we rarely experience any issues with news post. However, as the translation is carried out by third part tool there is a possibility for error to cause the occasional inaccuracy. We therefore require you to accept this disclaimer before confirming any translation news with us.
If you are not willing to accept this disclaimer then we recommend reading news post in its original language.
